Osteoarthritis is a leading cause of disability in developed countries. While knee MRI is commonly performed to evaluate structural cartilage and synovium modifications, there is a strong need for imaging markers that are sensitive to early changes induced by the disease, before structural modifications will occur. In early stages, OA is characterized by alterations in collagen and glycosaminoglycan content, which can be measure with quantitative MR. Together with an highly multidisciplinary team, I am investigating the potential of T2 and T1rho quantitative MRI as possible outcome measures in a clinical trial where a personalized modified gait training is tested in painful knee OA. I have also led the development of a distortion-free diffusion MRI method to assess cartilage involvement in children with juvenile idiopathic arthritis. We are also investigating the potential of diffusion MRI to characterize cartilage and synovium biochemistry in knee OA.
Publications
A noninvasive MRI based approach to estimate the mechanical properties of human knee ligaments.
Hamid Naghibi, Valentina Mazzoli, Kaj Gijsbertse, Gerjon Hannink, Andre Sprengers, Dennis Janssen, Ton Van den Boogaard, Nico Verdonschot
Journal of The Mechanical Behavior of Biomedical Materials, vol. 93, 2019 Mar 30, pp. 43-51
Anouk M Barendregt, Valentina Mazzoli, J Merlijn van den Berg, Taco W Kuijpers, Mario Maas, Aart J Nederveen, Robert Hemke
Pediatric Radiology, vol. 50(3), 2020 Jan 29, pp. 371-379
Juvenile Idiopathic Arthritis: Diffusion-weighted MRI in the Assessment of Arthritis in the Knee.
Anouk M Barendregt, Valentina Mazzoli, E Charlotte van Gulik, Dieneke Schonenberg-Meinema, Amara Nassar-Sheikh Al Rashid, Charlotte M Nusman, Koert M Dolman, J Merlijn van den Berg, Taco W Kuijpers, Aart J Nederveen, Mario Maas, Robert Hemke
Radiology, vol. 295(2), 2020 Feb 9, pp. 373-380
Lauren Watkins, James MacKay, Bryan Haddock, Valentina Mazzoli, Scott Uhlrich, Garry Gold, Feliks Kogan
The Journal of Nuclear Medicine, vol. 61, 2020 Mar 30, pp. 182-182
Lauren E. Watkins, Elka B. Rubin, Valentina Mazzoli, Scott D. Uhlrich, Arjun D. Desai, Marianne Black, Gabe K. Ho, Scott L. Delp, Marc E. Levenston, Gary S. Beaupré, Garry E. Gold, Feliks Kogan
NMR in Biomedicine, vol. 33(8), 2020 Apr 22
Hollis A Crowder, Valentina Mazzoli, Marianne S Black, Lauren E Watkins, Feliks Kogan, Brian A Hargreaves, Marc E Levenston, Garry E Gold
Journal of Orthopaedic Research, 2021 21
